There are many important, and splendid, frescoes in Florence, among them the cenacoli (Last Supper paintings), all of which are frescoes. To get you started, here is a list of frescoes I believe should not be missed:
The Brancacci Chapel: Masolinos and Masaccios famous frescoes.
The Palazzo Medici-Riccardi: Benozzo Gozzolis three-panel fresco cycle, one of the most important fresco cycles of the Renaissance, of the Procession of the Magi.
The Palazzo Vecchio: the Quartiere di Eleonora di Toledo, rooms decorated with frescoes representing the allegories of illustrious women, and the Cappella di Eleonora, splendidly decorated by Bronzino.
Santa Maria Novella: Masaccios unforgettable fresco of the Trinity; Paolo Uccellos damaged, but still remarkable, frescoes of the Stories from Genesis in the Green Cloister, and Domenico Ghirlandaios masterpiece: the fresco cycle of the Life of Mary and St. John the Baptist in the Cappella Tornabuoni.
Chiesa Santa Trinita: Domenico Ghirlandaios Life of St. Francis in the Sassetti Chapel and Lorenzo Monacos (one of my favorite painters) beautiful frescoes of the Life of the Virgin, and his altarpiece of the Annunciation.
The Duomo: the two frescoes of equestrian sculptures by Paolo Uccello, and the huge, recently restored, fresco inside the octagonal dome, depicting the Last Judgment by Giorgio Vasari and Federico Zuccari.
The monastery of San Marco: Fra Angelicos exquisite Annunciation, probably his most celebrated work of art. Also visit the fresco in his cell, which served as inspiration for meditation.
Chiesa Santa Felicita, in the Capponi Chapel: Pontormos Deposition (my very favorite fresco in Florence).
Oratorio dei Buonomini di San Martino, in Piazza San Marino, close to Piazza della Signoria: a small chapel, with lovely frescoes portraying acts of charity, by the workshop of Ghirlandaio; it is not often mentioned in guidebooks, but it is interesting because of the subject matter.
To locate these and the many, many other frescoes in the city, pick up a good guide book, like Blue Guide Florence, which has in-depth details on the best frescoes in the city. Check www.theflorentine.net as well. Youll find my previous columns on particular frescoes, and, in the July 12 and July 26 2007 issues, The Florentines list of Florence museums, galleries, and monuments, with information about hours and entrance fees.